The Secunderabad–Hazrat Nizamuddin Duronto Express is a Superfast Express train of the Indian Railways connecting Secunderabad (SC) to Delhi Hazrat Nizamuddin (NZM). It is the fastest train between New Delhi and Secunderabad with a travel time of 22 hours. It is currently being operated with 12285 / 12286 train numbers.

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| Overview | |||||
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| Service type | Duronto Express | ||||
| First service | 14 March 2010 | ||||
| Current operator(s) | Indian Railways (SCR) | ||||
| Route | |||||
| Termini | Secunderabad Junction (SC) Delhi Hazrat Nizamuddin (NZM) | ||||
| Stops | 4 | ||||
| Distance travelled | 1,660 km (1,030 mi) | ||||
| Average journey time | 12285 – 21 hrs 5 mins, 12286 – 22 hrs 10 mins | ||||
| Service frequency | Bi-weekly | ||||
| Train number(s) | 12285 U, 12286 D | ||||
| On-board services | |||||
| Class(es) | AC 1, AC 2, AC 3, Sleeper class, General | ||||
| Seating arrangements | No | ||||
| Sleeping arrangements | Yes | ||||
| Catering facilities | Yes | ||||
| Observation facilities | LHB coaches | ||||
| Technical | |||||
| Rolling stock | LHB Coaches | ||||
| Track gauge | Broad – 1,676 mm (5 ft 6 in) | ||||
| Operating speed | 12285 76.76 km/h (47.70 mph) (Average) 12286 74.00 km/h (45.98 mph) (Average) | ||||
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Both trains are hauled by a Lallaguda-based WAP-7 locomotive on its entire journey.
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